From http://www.mozilla.org/support/firefox/mouse
A Middle-click on a tab closes it on Windows by default. However, in Linux it pastes whatever is currently in the Clipboard and visits that site (or performs a search). This can be changed by setting the middlemouse.contentLoadURL pref to either true (for the Content Load URL feature) or false (for closing the tab).
To access the middlemouse.contentLoadURL pref, type "about:config" in your location bar.



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