Sounds like you're having the typical WINE headaches. Problem is, wine is still experimental, whatnot, so alot of programs have problems.
The only two things you can really try are;
1) Make sure you have the latest build from http://www.winehq.com (builds are released about once a month).
2) Edit the config file ~/.wine/config and make sure the settings are correct for your system.
Hope that helps for you. Let me know if you can get anything working at all with wine.